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Rhodopsin Antibody: Dylight 633, Monoclonal

Rhodopsin Antibody: Dylight 633, Monoclonal
351,06 €
Artikelnummer: STRSMC-176D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Rhodopsin Antibody: Dylight 633, Monoclonal, Clone: 4D2, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Bovine Rhodopsin Monoclonal IgG1
Target: Rhodopsin
Purification: Protein G Purified
Specificity: Detects ~40kDa. Binds specifically to the N-terminus of Rhodopsin. Does not detect Rhodopsin in invertebrates.
Conjugate: Dylight 633
Immunogen Species: Bovine
Cellular Location: Membrane
Immunogen: Bovine Rhodopsin
Scientific Background: Rhodopsin consists of the protein moiety opsin and a reversibly covalently bound cofactor, retinal. Opsin, a bundle of seven membrane embedded alpha-helices, binds retinal, a photo reactive chromophore, in a central pocket (2, 3). In addition to being the pigment of the retina that is responsible for both the formation of the photoreceptor cells, its function is to specifically convey information stored in the specific geometry of the chormophore to the surface of the molecule upon light absorption (2). In the active state, rhodopsin activates transduction, a GTP binding protein. Once activated, transduction promotes the hydrolysis of cGMP by phosphodiesterase. Rhodopsin's activity is believed to be shut off by its phosphorylation followed by binding of the soluble protein arrestin (4).Mutations in the rhodopsin gene lead to retinitis pigmentosa, which can be inherited as an autosomal dominant, an autosomal recessive or an X-linked recessive disorder (5).
Reference: 1. Molday R.S., Hicks D., and Molday L. (1987) Invest Ophthalmol Vis Sci. 28: 50-61.2. Ridge K.D., Lee S.S.J., and Abdulaev N.G. (1996) J of Biol Chem. 271: 7860-7867.3. Matsuyama T., Yamashita T., Imai H. and Shichida Y. (2009) J Biol Chem. Manuscript M109.063875.4. Feurstein S.E., et al. (2009) Biochemistry. 48(45): 10733-10742.5. Iannaccone A., et al. (2006) Vision Res. 46(27): 4556-4567.

Zusatzinformation

Artikelnummer STRSMC-176D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-176D-DY633
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Amphibian, Bird (Avian), Fish, Mammalian, Shark (Squalus Acanthias)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download