Mouse anti-CD44, clone MEM-263, R-PE (Monoclonal)

Clone Number: MEM-263

Conjugate: PE

Immunogen: COS-7 cells (African Green Monkey).

Concentration: n/a

Storage buffer: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide

Additional info: CD44 is a transmembrane glycoprotein expressed on the surface of most cells, which serves as a receptor for hyaluronan. CD44 mediates angiogenesis, cell adhesion, proliferation and migration, it is thus important for lymphocyte activation, recirculation and homing, it can thus serve e.g. as a modulator of macrophage recruitment in response to pathogen. Although CD44 functions are essential for physiological activities of normal cells, elevated CD44 expression correlates with poor prognosis in many carcinomas, facilitating tumour growth and metastasis, antiapoptosis and directional motility of cancer cells.