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DMPO Antibody: Dylight 594, Monoclonal

DMPO Antibody: Dylight 594, Monoclonal
366,97 €
Artikelnummer: STRSMC-189D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
DMPO Antibody: Dylight 594, Monoclonal, Clone: N1664A, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-DMPO Monoclonal IgG1
Target: DMPO
Purification: Protein G Purified
Specificity: Recognizes DMPO, DMPO-octanoic acid, DMPO-protein adducts and DMPO-DNA adducts. Does not cross react with non-adducted proteins or DNA.
Conjugate: Dylight 594
Immunogen: 5,5-dimethyl-2-(8-octanoic acid)-1-pyrrolone-N-oxide conjugated to Ovalbumin
Scientific Background: The formation of free radicals and other highly reactive oxygen species has been implicated in the pathogenesis of many disease states (1). The ability to identify these species is crucial, and spin trapping has accomplished this goal. DMPO (5,5-dimethyl-1-pyrroline N-oxide) is one of the least toxic to cells and animals, and possesses convenient pharmacokinetics (uptake, distribution, metabolism and excretion) in biological systems (2-6). Recent studies have determined that nitric oxide may substantially affect the quantitative determination of DMPO adducts, and therefore extra caution is required when studying generation of these species in the presence of nitric oxide or its radicals (1). DMPO adducts can be generated with protein and DNA radicals (7).
Reference: 1. Reszka K.J., et al. (2006) Nitric Oxide 15: 133-141.2. Ramirez D.C., Gomez-Mejiba S.E., and Mason R.P. (2007) Nat Protoc. 2(3): 512-522.3. Khan N., et al. (2003) Free Radic. Biol. Med 34:1473–1481.4. Haseloff R.F., et al. (1997) FEBS Lett 418:73–75.5. Schaefer C.F., Janzen E.G., West M.S., Poyer J.L., and Kosanke S.D. (1996) Free Radic. Biol. Med 21:427–436.6. Anzai K., et al. (2003) Arch. Biochem. Biophys 415:251–256.7. Free Radic Biol Med. (2009) April 1; 46(7): 853–865. doi:10.1016/j.freeradbiomed.2008.12.020.8. Chatterjee S., et al. (2009) Free Radic. Med.and Biol. 46: 454-461.

Zusatzinformation

Artikelnummer STRSMC-189D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-189D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Various species
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download