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AHA1 Antibody: Dylight 633, Monoclonal

AHA1 Antibody: Dylight 633, Monoclonal
328,79 €
Artikelnummer: STRSMC-198D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
AHA1 Antibody: Dylight 633, Monoclonal, Clone: 4H9-D7, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human AHA1 Monoclonal IgG1 Kappa
Target: AHA1
Purification: Protein G Purified
Specificity: Detects ~38kDa, can run up to 45kDa on SDS Page. It sees human Aha1, Mouse Aha1 and Mouse Aha2.
Conjugate: Dylight 633
Immunogen Species: Human
Cellular Location: Cytoplasm, Endoplasmic Reticulum
Immunogen: Human Aha1, his tagged
Scientific Background: Aha1 is a member of the HSP90 cochaperone family, and is thought to stimulate HSP90 ATPase activity by competing with p23 and other co-chaperones for HSP90 binding (1, 2). It may affect a step in the endoplasmic reticulum to Golgi trafficking. Aha1 also interacts with HSPCA/HSP90 and with the cytoplasmic tail of the vesicular stomatistis virus glycoproteins (VSV G) (3). Aha1 is expressed in numerous tissues, including the brain, heart, skeletal muscle, and kidney, and at low levels, the liver and placenta. Aha1 might be a potential therapeutic strategy to increase sensitivity to HSP inhibitors (4).
Reference: 1. Hainzl O., Lapina M.C., Buchner J., Richter K. (2009) J Biol Chem. Epub.2. Harst A., Lin H., Obermann W.M. (2005) Biochem J. 387 (pt.3): 789-796.3. Lotz G.P., Brychzy A., Heinz S., Obermann W.M. (2008) J Cell Sci. 121(pt.5): 717-723.4. Holmes J.L., Sharp S.Y., Hobbs S., Workman P. (2008) Cancer Res. 68(4): 1188-1197.

Zusatzinformation

Artikelnummer STRSMC-198D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-198D-DY633
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download