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Alpha B Crystallin Antibody: Dylight 405, Monoclonal

Alpha B Crystallin Antibody: Dylight 405, Monoclonal
385,00 €
Artikelnummer: STRSMC-159B-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Alpha B Crystallin Antibody: Dylight 405, Monoclonal, Clone: 1A7.D5, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human Alpha B Crystallin Monoclonal IgG1
Target: Alpha B Crystallin
Purification: Protein G Purified
Specificity: Detects ~20kDa (Predicted mol. weight is ~21kDa). Does not cross-react with αA-crystallin, βL-crystallin, βH-crystallin, γ-crystallin, HSP25, HSP27 or HSP47 proteins.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Cytoplasm, Nucleus
Immunogen: Native Alpha B Crystallin
Scientific Background: The alpha-crystallins are major water-soluble lens structural proteins of the vertebrate eye that are related to the small heat shock protein family. The alpha-crystallins possess structural and functional similarities with HSP25 and HSP27 (1). Mammalian lens cystallins are divided into alpha, beta and gamma families. Alpha and beta families are further divided into acidic and basic groups (Alpha-A and Alpha-B respectively). In the lens, alpha-crystallin primarily functions to maintain proper refractive index, however it can also function as a molecular chaperone that binds to the denatured proteins, keeping them in solution and thereby maintaining the translucency of the lens. When cellular stress occurs, alpha-crystallin enters its' phosphorylated state and may serve a structural control function and play a role in protein maintenance (2). In addition to their interaction with proteins, alpha-crystallins also interact with native molecules such as membrane proteins, Golgi matrix protein, structural proteins, nuclear proteins and DNA (3, 4, 5, 6, and 7). Two other functions are an autokinase activity and participation in the intracellular architecture, and it has also been proven that both alpha-A and B prevent apoptosis by inhibiting caspases (8). Specifically, alpha-B cystallin is found in many cells and organs outside the lens, and alpha B is overexpressed in several neurological disorders and in cell lines under stress conditions (9).
Reference: 1. Merck K.B. et al. (1993) J Biol Chem. 268: 1046-1052.2. Horwitz J. (1992) Proc Natl Acad Sci USA. 89(21): 10449-10453.3. Cobb B.A. and Petrash J.M. (2002) Biochemistry. 41: 483-4904. Horwitz J. (2003) Exp Eye Res. 76: 145-153.5. Bullard B. et al. (2004) J Biol Chem. 279: 7917-7924.6. Gangalum R.K., Schibler M.J. and Bhat S.P. (2004) J Biol Chem. 279: 43374.43377.7. Maddala R. and Rao V.P. (2005) Exp Cell Res. 306: 203-215.8. Yaung J., et al. (2007) Molecular Vision 13: 566-577.9. Head M.W. et al. (2000) Neuropathol Appl Neurobiol. 26: 304-312.10. Banduseela V.C., et al. (2009) Physiol Genomics. 39(3): 141-159.

Zusatzinformation

Artikelnummer STRSMC-159B-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-159B-DY405
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Cow (Bovine), Human, Pig (Porcine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download