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CD74 Antibody: Dylight 488, Monoclonal

CD74 Antibody: Dylight 488, Monoclonal
292,73 €
Artikelnummer: STRSMC-116D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
CD74 Antibody: Dylight 488, Monoclonal, Clone: PIN.1, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human CD74 Monoclonal IgG1
Target: CD74
Purification: Protein G Purified
Specificity: Detects ~33-35kDa protein doublet corresponding to the molecular mass of the p33 and p35 forms of human CD74.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Cell Membrane, Endoplasmic Reticulum, Endoplasmic Reticulum Membrane, Golgi Apparatus, Endosome, Lysosome
Immunogen: Human CD74 invariant chain synthetic peptide
Scientific Background: CD74 is a non-polymorphic type II integral membrane protein. It has a short N-terminal cytoplasmic tail of 28 amino acids, followed by a single 24-aa transmembrane region and an approximately 150-aa lumenal domain (1). The CD74 chain is thought to function mainly as an MHC class II chaperone, which promotes ER exit of MHC class II molecules, directs them to endocytic compartments, prevents peptide binding in the ER, and contributes to peptide editing in the MHC class II compartment.Class II MHC and Ii expression was believed to be restricted to classical antigen-presenting cells (APC); however, during inflammation, other cell types, including mucosal epithelial cells, have also been reported to express class II MHC molecules (2). Experiments that investigate cell-surface CD74 are complicated by the fact that CD74 remains on the cell surface for a very short time. The surface half-life of CD74 was calculated to be fewer than 10 minutes (3). CD74 however has also recently been shown to have a role as an accessory-signaling molecule because of its high-affinity binding to the pro-inflammatory cytokine, macrophage migration-inhibitory factor (MIF) (3). The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases (4).
Reference: 1. Becker-Hermann, S., Arie, G., Medvedovsky H, Kerem A, and Shachar I. (2005) Mol Bio Cell. 16(11):5061-9.2. Barrera CA., et al (2005) J Histochem Cytochem 53 (12): 1481-9.3. Starlets D., et al. (2006) Blood. 107 (12): 4807-4816.4. Burton JD., et al. (2004). Clin Cancer Res. 10(19): 6606-11.5. Denzin L.K., Hammond, C. and Cresswell, P. (1996) J. Exp. Med. 184: 2153-2165.6. Denzin L.K., Robbins N.F., Carboy-Newcomb C. and Cresswell P. (1994) Immunity 1: 595-606.

Zusatzinformation

Artikelnummer STRSMC-116D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-116D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Flow Cytometry, Fluorescence-Activated Cell Sorting, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download