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CENP-A Antibody: APC/Cy7, Monoclonal

CENP-A Antibody: APC/Cy7, Monoclonal
416,82 €
Artikelnummer: STRSMC-202D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
CENP-A Antibody: APC/Cy7, Monoclonal, Clone: 5A7-2E11, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human CENP-A Monoclonal IgG1
Target: CENPA
Purification: Protein G Purified
Specificity: Detects ~18kDa. Recognizes Human CENP-A.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Nucleus, Chromosome, Centromere, Kinetochore
Immunogen: Synthetic peptide corresponding to a portion of human CENP-A
Scientific Background: A replicated chromosome includes two kinetochores that control chromosome segregation during mitosis. The Centromere Protein-A, CENP-A, is a Histone H3-like protein that contains a C-terminal H3-like domain, which is required for centromere localization of CENP-A, and an antigenic N-terminal domain. CENP-A, originally isolated from HeLa cells, is essential for kinetochore targeting of CENP-C. In the presence of DNA CENP-A forms an octa-meric complex with histones H4, H2A, H2B. CENP-A specifically localizes to active centromeres and is a component of specialized centromeric nucleosomes, on which kinetochores are assembled. CENP-A is essential for nucleosomal packaging of centromeric DNA at interphase and functions as a centromere formation marker on the chromosome.
Reference: 1. Rieder C.L., et al. (1998) Trends Cell Biol. 8: 310-318.2. Choo K.H. (2000) Trends Cell Biol. 10: 182-188.3. Muro Y., et al. (2000) Clin. Exp. Immunol. 120: 218-223.4. Howman E.V., et al. (2000) Proc. Natl. Acad. Sci. USA 97: 1148-1153.

Zusatzinformation

Artikelnummer STRSMC-202D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-202D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download