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DUX4 Antibody: Dylight 633, Monoclonal

DUX4 Antibody: Dylight 633, Monoclonal
351,06 €
Artikelnummer: STRSMC-192D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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DUX4 Antibody: Dylight 633, Monoclonal, Clone: P2B1, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human DUX4 Monoclonal IgG1
Target: DUX4
Purification: Protein G Purified
Specificity: Detects ~45kDa. No cross-reactivity with DUX4c.
Conjugate: Dylight 633
Immunogen Species: Human
Cellular Location: Nucleus
Immunogen: C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag
Scientific Background: DUX4, or double homeobox4, is a human protein that is a transcriptional activator of paired-like homeodomain transcription factor 1 (1). Clinically it is a facioscapulohumeral muscular dystrophy candidate gene that appears to have a toxic gain of function (2-4). In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle and possibly other differentiated tissues (5).
Reference: 1. Entrez Gene: “Dux4 Double Homeobox, 4”2. Dixit M., et al., (2007) Proc. Natl Acad Sci. USA. 104(46): 18157-18162.3. Kowaljow V., et al. (2007) Neuromuscl Disord. 17(8): 611-623.4. Lemmers R., et al. (2010) Science Express. 329(5999): 1650-1653.5. Snider L., et al. (2010) PLoS Genetics. 6:1-14.

Zusatzinformation

Artikelnummer STRSMC-192D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-192D-DY633
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download