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ERp57 (GRP58) Antibody: Dylight 488, Monoclonal

ERp57 (GRP58) Antibody: Dylight 488, Monoclonal
411,52 €
Artikelnummer: STRSMC-168B-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
ERp57 (GRP58) Antibody: Dylight 488, Monoclonal, Clone: Map.ERp57, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human ERp57 (GRP58) Monoclonal IgG1
Target: ERp57
Purification: Protein G Purified
Specificity: Detects ~57kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Endoplasmic Reticulum, Endoplasmic Reticulum Lumen, Melanosome
Immunogen: Human recombinant ERp57 (Grp58)
Scientific Background: ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).
Reference: 1. Herbert D.N. and Molinari M. (2007) Physiol Rev. 87: 1377-1408.2. Williams D.B. (2005) J Cell Sci. 119: 615-6233. Maattanen P., et al. (2006) Biochem Cell Biol. 84: 881-889.4. Oliver J.D., et al. (1999) Mol Bio Cell. 10: 2573-2582.5. Oliver J.D., et al. (1997) Science 275: 86-88.6. Solda T., et al. (2006) J Biol Chem 281: 6219-6226.7. Kimura T., et al. (2005) Biochem Biophys Research Communications. 331 (1): 224-230.8. Chen, G., et al. (2002) Clin Cancer Res 8(7): 2298-2305.9. Tan, P., et al. F. (2002) J Immunol 168(4): 1950-1960.

Zusatzinformation

Artikelnummer STRSMC-168B-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-168B-DY488
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Cow (Bovine), Dog (Canine), Guinea Pig, Hamster, Human, Monkey (Primate), Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download