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Mouse Anti-Human ERp57 (GRP58) Monoclonal IgG1 Dylight 633

Mouse Anti-Human ERp57 (GRP58) Monoclonal IgG1 Dylight 633
387,54 €
Artikelnummer: STRSMC-168B-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Mouse Anti-Human ERp57 (GRP58) Monoclonal IgG1 Dylight 633, Clone: Map.ERp57

Details

ERp57, also known as Glucose Regulated Protein 58 (Grp58), Hormone-Induced Protein-70 (HIP-70) and microsomal Carnitine Palmitoyltransferase, is a member of the protein disulfide isomerase family, containing two canonical CXHC tetrapeptide active site motifs (1-5). It has quite a few diverse roles. It functions as an accessory oxidoreductase involved in disulfide bond formation. In the ER, ERp57 interacts with membrane bound calnexin and soluble calreticulin (lectin chaperones) via their praline rich P-domain arms. Lectin chaperones bind nascent non-native glycoproteins, and position ERp57 to act upon the immature or misfolded glycoproteins that possess mono-glycosylated side chains. ERp57 deletion impairs posttranslational phases of influenza hema-glutinin folding, and causes accelerated release of MHC-I molecules, resulting in the coupling of sub-optimal peptides and reduced expression and stability on the cell surface (6). ERp57 also contains two thioredoxin active-site sequences, CGHC and an estrogen-binding domain. ERp57 is induced by both estrogen and leuteinizing-hormone-releasing hormone in the hippocampus (7).

0.5 µg/ml of SMC-168 was sufficient for detection of ERp57 in 10 µg of heat shock Heal Lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Zusatzinformation

Artikelnummer STRSMC-168B-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-168B-DY633
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Cow (Bovine), Dog (Canine), Guinea Pig, Hamster, Human, Monkey (Primate), Mouse (Murine), Pig (Porcine), Rabbit, Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG
Gene ID NCBI (externer Link)
Datenblatt Auf Anfrage
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