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FIH Antibody: Dylight 488, Monoclonal

FIH Antibody: Dylight 488, Monoclonal
354,24 €
Artikelnummer: STRSMC-182D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
FIH Antibody: Dylight 488, Monoclonal, Clone: FIH 162c, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human FIH Monoclonal IgG1
Target: FIH
Purification: Protein G Purified
Specificity: Detects ~45kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Nucleus
Immunogen: Full length human FIH expressed in E.coli BL21 (DE3) cells
Scientific Background: FIH, Factor inhibiting HIF1 (hypoxia-inducible factor), is an asparaginyl hydroxylase. FIH in conjunction with VHL represses HIF-1 transcriptional activity by disrupting the interaction of HIF-1 with the transcriptional co-activators CBP/p300, and by recruiting histone deacetylases. FIH activity is inhibited during hypoxia (1-3). Recent studies show that low nuclear expression of FIH is a strong independent prognostic factor for a poor overall survival in clear cell renal cell carcinoma (4).
Reference: 1. Stolze I.P., et al. (2004) J Bio Chem. 42719-42725.2. Soilleux E.J., et al. (2005) Histopathology 47:602-610.3. Moon H., Han S., Park H., Choe J. (2010) Mol Cells. 29(5): 471-474.4. Kroeze S.G., et al. (2010) Eur J Cancer. Epub.

Zusatzinformation

Artikelnummer STRSMC-182D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-182D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download