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GRP170 Antibody: Dylight 405, Monoclonal

GRP170 Antibody: Dylight 405, Monoclonal
364,85 €
Artikelnummer: STRSMC-233D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
GRP170 Antibody: Dylight 405, Monoclonal, Clone: 6G7-2H5, Host: Mouse, Isotype: IgG2a

Details

Mouse Anti-Human GRP170 Monoclonal IgG2aK
Target: GRP170
Purification: Protein G Purified
Specificity: Detects ~170kDa.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Endoplasmic Reticulum, Endoplasmic Reticulum Lumen
Immunogen: Raised against a synthetic peptide of human GRP170
Scientific Background: GRP170, also known as ORP150, is the largest member of glucose-regulated Antibodys, and acts as a human chaperone Antibody. It is thought to play an important role in Antibody folding and secretion in the ER. Suppression of the Antibody is associated with accelerated apoptosis, therefore having an important cryoprotective role in hypoxia-induced cellular pertubation. This cryopotective role has led to an anti-tumor immune response, which will hopefully lead to therapeutic immunizations against cancers (1). GRP170 has also been shown to bind with dendritic cells and provide the danger signals to induce anti-tumor immune responses (2).
Reference: 1. Wang H., et al. (2014) Front Oncol. 4: 377.2. Manjili M.H., et al. (2006) Immun. Cell Biol. 84: 203-208.

Zusatzinformation

Artikelnummer STRSMC-233D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-233D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG2
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download