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GRP78 Antibody: Dylight 405, Monoclonal

GRP78 Antibody: Dylight 405, Monoclonal
331,97 €
Artikelnummer: STRSMC-195D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
GRP78 Antibody: Dylight 405, Monoclonal, Clone: 1H11-1H7, Host: Mouse, Isotype: IgG2b

Details

Mouse Anti-Human GRP78 Monoclonal IgG2b
Target: GRP78
Purification: Protein G Purified
Specificity: Detects ~78kDa.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Endoplasmic Reticulum, Endoplasmic Reticulum Lumen, Melanosome
Immunogen: His-tagged human GRP78
Scientific Background: GRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5' non-translated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed (1).GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis (2). Lou et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival (3).In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress (4), and its protein levels are reduced in the brains of Alzheimer's patients (5). Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs (6, 7).
Reference: 1. Cho S., et al. (2007) Mol Cell Biol. 27(1): 368-83.2. Yang Y., et al. (1998) J Biol Chem 273: 25552-25555.3. Luo S., et al (2006) 26 (15): 5688-97.4. Yu Z., et al. (1999) Exp Neurol. 15: 302-314.5. Koomagi R., et al. (1999) Anticancer Res. 19:4333-4336.6. Laquerre S., et al. (1998) J. Virology 72: 4940-4949.7. Dong D., et al. (2005) Cancer Res 65(13): 5785-91.

Zusatzinformation

Artikelnummer STRSMC-195D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-195D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Cow (Bovine), Frog (Xenopus Laevis), Fungi, Hamster, Human, Monkey (Primate), Mouse (Murine), Rabbit, Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG2
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download