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HIF2 alpha Antibody: APC/Cy7, Monoclonal

HIF2 alpha Antibody: APC/Cy7, Monoclonal
406,21 €
Artikelnummer: STRSMC-185D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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HIF2 alpha Antibody: APC/Cy7, Monoclonal, Clone: EP190B, Host: Mouse, Isotype: IgG1


Mouse Anti-Human HIF2 alpha Monoclonal IgG1
Target: HIF 2 alpha
Purification: Protein G Purified
Specificity: Detects ~100kDa. Specific for HIF2 Alpha.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Nucleus
Immunogen: GST-human EPAS-1 (HIF2alpha) amino acids 535-631 fusion protein
Scientific Background: Members of the hypoxia-inducible factor (HIF) family of transcription factors regulate the cellular response to hypoxia (1). HIF2-Alpha is involved in catecholamine homeostasis, vascular remodeling, physiological angiogenesis and adipogenesis. It is overexpressed in many cancerous tissues, but its exact role in tumourprogression remains to be clarified (2). Studies suggest that in the case of non-small cell lung cancer, HIF2-Alpha actually is a promoter of tumor growth and progression in a solid tumor (1). Other data suggests that HIF2-Alpha is an important regulator of innate immunity, and therefore may be useful in the therapeutic target for treating inflammatory disorders and cancer (3).
Reference: 1. Kim W.Y., et al. (2009) J Clin Invest. 119(8): 2160-2170.2. Favier J., Lapointe S., Maliba R. and Sirois M.G. (2007) BMC Cancer. 7:139.3. Imtiyaz H.Z., et al. (2010) J Clin Invest. 120(8): 2699-2714.


Artikelnummer STRSMC-185D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-185D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download