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Histone H3 Antibody (tri Methyl Lys4): APC/Cy7, Monoclonal

Histone H3 Antibody (tri Methyl Lys4): APC/Cy7, Monoclonal
397,73 €
Artikelnummer: STRSMC-252D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Histone H3 Antibody (tri Methyl Lys4): APC/Cy7, Monoclonal, Clone: 2E11, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human Histone H3 (tri Methyl Lys4) Monoclonal IgG1
Target: Histone H3
Specificity: Detects endogenous Histone H3 (tri methyl K4) protein.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Nucleus, Chromosome
Immunogen: Prepared by immunizing synthetic peptide coupled to KLH.
Scientific Background: Histone H3 is a 17 kD nuclear protein that is a component of an octamer containing pairs of each of four core histones (H2A, H2B, H3, H4). The core histones create nucleosome structure of chromosomal fiber in eukaryotes and are dynamic in gene regulation. The histones exhibit cell cycle-dependent transcriptional regulation except for the variant H3.3 which is cell cycle-independent. Histone H3 can be modified by phosphorylation, acetylation, ubiquitination, ribosylation, and methylation. Histone H3 has been shown to interact with Rsk-2, MSK1, GCN5 family of HATs, HDACs, PARP, SET7/9, and CARM1. Histones play a cental role in transcription regulation, DNA repair, DNA replication and chromosomal stability.
Reference: 1. Wu R., et al. (1981) Cell. 27:321.2. Strahl B., et al. (2000) Nature. 403:41.3. Bauer U., et al. (2002) EMBO Rep. 3:39.4. Frank D., et al. (2003) Gene. 312:135.

Zusatzinformation

Artikelnummer STRSMC-252D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-252D-APCCY7
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Western Blotting
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download