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HSP47 Antibody: Dylight 594, Monoclonal

HSP47 Antibody: Dylight 594, Monoclonal
432,73 €
Artikelnummer: STRSMC-203B-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
HSP47 Antibody: Dylight 594, Monoclonal, Clone: 1C4-1A6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human HSP47 Monoclonal IgG1 Kappa
Target: HSP47
Purification: Protein G Purified
Specificity: Detects 47kDa.
Conjugate: Dylight 594
Immunogen Species: Human
Cellular Location: Endoplasmic Reticulum, Endoplasmic Reticulum Lumen
Immunogen: Human HSP47, full length
Scientific Background: HSP47 is a chaperone protein, member of the superfamily of serine proteinase inhibitors. Also known as SERPINH1, a serine proteinase inhibitor. It is a stress protein that resides in the endoplasmic reticulum, has an active role on the intracellular process of folding, assembly and secretion of pro-collagens. Recent studies have shown the association of on an increased expression of HSP47 around fibrotic lesions (1).The identification of a novel biomarker on cell therapies aimed to reduce the progression of fibrotic diseases, could be used potentially as a universal marker, since HSP47 binds a single substrate (2). Type I collagen is fundamental during the healing process after a myocardial infarction. It is critical in the position of collagen-produced cells and the assembly of collagen fibrils (3).
Reference: 1. Razzaque MS., Taquchi T., (1999) Histol Histopathol. 14 (4): 1999-212.2. Taguchi T., et al. (2011) Acta Histochem Cytochem. 44(2):35-41. 3. Nong Z., et al. (2011) Am J Pathol. 197(5): 2189-96.

Zusatzinformation

Artikelnummer STRSMC-203B-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-203B-DY594
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download