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LC3C Antibody: Dylight 405, Monoclonal

LC3C Antibody: Dylight 405, Monoclonal
355,30 €
Artikelnummer: STRSMC-212A-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
LC3C Antibody: Dylight 405, Monoclonal, Clone: VB2, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human LC3C Monoclonal IgG1
Target: LC3C
Purification: Protein G Purified
Specificity: Specific for LC3C. Does not detect LC3A, LC3B, GABARAP, GABARAPL1 or GABARAPL2.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Cytoplasm, Cytoskeleton, Cytoplasmic Vesicle, Autophagosome, Autophagosome Membrane
Immunogen: Peptide derived from C-terminal region of human LC3C protein
Scientific Background: Light chain 3 (LC3) is a microtubule-associated protein with an approximate molecular mass of 17kDa, and can be found ubiquitously throughout mammalian tissue. LC3 plays a role in autophagy; once the autophagic process is initiated in a cell, LC3 is conjugated to phosphatidylethanolamine to form LC3-II. This molecule is recruited to the autophagosome at the time of fusion with lysosomes, and LC3-II in autolysosomal lumen is degraded. Therefore, monitoring LC3 is an important tool for detecting autophagy and autophagy-related processes. LC3C is one of three isoforms which exhibits the lowest expression relative to the other two isoforms. Its highest expression is seen in placenta, lung and ovary.
Reference: 1. Tanida, I., Ueno, T., & Kominami, E. (2008). LC3 and Autophagy. Methods Mol Biol. 445: 77-88.2. He, H., Dang, Y., Dai, F., Guo, Z., Wu, J., She, X., et al. (2003). J Biol Chem. 278(31): 29278-87.

Zusatzinformation

Artikelnummer STRSMC-212A-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-212A-DY405
Verpackungseinheit 50 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download