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p23 Antibody: Dylight 488, Monoclonal

p23 Antibody: Dylight 488, Monoclonal
299,09 €
Artikelnummer: STRSMC-156D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
p23 Antibody: Dylight 488, Monoclonal, Clone: JJ6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human p23 Monoclonal IgG1
Target: p23
Purification: Protein G Purified
Specificity: Detects ~23kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Cytoplasm
Immunogen: Recombinant human full length p23 protein
Scientific Background: p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 does not have any structural homology with any other known proteins (1). p23 was first discovered as a part of the HSP90-progesterone receptor complex along with HSP70, p54 and p50 (1). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology.
Reference: 1. Johnson J.L., Beito T. G., Krco C.J. & Toft D.O. (1994) Mol Cell Biol 14: 1956-63.2. Weikl T., Abelmann K. & Buchner J. (1999) J Mol Biol 293: 685-91.3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A. & Toft, D.O. (2000) J Biol Chem 275: 23045-52.4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50.5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70.6. Holt S.E., et al. (1999) Genes Dev 13: 817-26.7. Hu J., Toft D., Anselmo D. & Wang X. (2002) J Virol 76: 269-79.8. Felts, S.J. & Toft D.O. (2003) Cell Stress Chaperones 8: 108-13.9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia.

Zusatzinformation

Artikelnummer STRSMC-156D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-156D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Chicken, Guinea Pig, Human, Mouse (Murine), Rabbit, Yeast
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download