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p38 alpha (MAP Kinase) Antibody: Dylight 405, Monoclonal

p38 alpha (MAP Kinase) Antibody: Dylight 405, Monoclonal
304,39 €
Artikelnummer: STRSMC-152D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
p38 alpha (MAP Kinase) Antibody: Dylight 405, Monoclonal, Clone: 9F12, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human p38 alpha (MAP Kinase) Monoclonal IgG1
Target: p38 MAPK
Purification: Protein G Purified
Specificity: Detects ~38kDa.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Cytoplasm, Nucleus
Immunogen: Full length recombinant protein expressed in E.coli cells
Scientific Background: The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
Reference: 1. Pearson, G. et al (2001). Endocrine Reviews 22 (2): 153-183.2. Fan, Y. et al (2007) Mol. Cells 23 (1): 30-38.3. Han, J. et al. (1994) Science 265: 808-811.4. Van, L. A., et al. (2004) Faseb J. 18: 1946−1948.5. Deng et al. (2003) Cell. 115: 61-70.6. Salojin KV, et al. (2006) J Immunol. 176 (3):1899-907.7. Medicherla S. et al. (2006). J Pharmacol Exp Ther.318(1): 99-107.

Zusatzinformation

Artikelnummer STRSMC-152D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-152D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download