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p53 Antibody: Dylight 488, Monoclonal

p53 Antibody: Dylight 488, Monoclonal
293,79 €
Artikelnummer: STRSMC-183D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
p53 Antibody: Dylight 488, Monoclonal, Clone: Pab 1801, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human p53 Monoclonal IgG1
Target: p53
Purification: Protein G Purified
Specificity: Detects ~53kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Cytoplasm, Nucleus, PML body, Endoplasmic Reticulum
Immunogen: Fusion protein (Human), amino acids 46-53
Scientific Background: The p53 protein (tumor protein 53 or TP53) is a DNA-binding cell cycle-regulating transcription factor that governs cell division and the fine balance between cell death and cell survival (1). P53 plays a critical role in tumor suppression and hence it is often described as "the guardian of the genome", "the guardian angel gene", or the "master watchman." This also refers to its role in conserving stability by preventing genome mutation (2). Defects in p53 are linked to >50% of human cancers, and restoring p53 function to these cancer cells can induce growth arrest and apoptosis (3). When p53 has been damaged, it can also lead to autoimmune disorders (4, 5).
Reference: 1. Georescu C.V., Saftoiu A., Georgescu C.C., Ciurea R. and Ciurea T. (2007) J Gastrointestin Liver Dis. 16(2): 133-9.2. Strachan T., et al. (1999) Human Molecular Genetics 2. Ch. 18: Cancer Genetics.3. Hansen J.E., et al. (2007) Cancer Research 67: 1769-1774.4. Di Cesare E., et al. (2001) Ann Clin Lab Sci 31: 253-8.5. Akere A., Otegbayo J.A. (2007) Singapore Med J. 48(1): 41-4.

Zusatzinformation

Artikelnummer STRSMC-183D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-183D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Radioimmunoassay (RIA), Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download