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SOD (EC) Antibody: Dylight 405, Monoclonal

SOD (EC) Antibody: Dylight 405, Monoclonal
358,48 €
Artikelnummer: STRSMC-167D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
SOD (EC) Antibody: Dylight 405, Monoclonal, Clone: 4GG11G6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human SOD (EC) Monoclonal IgG1 Kappa
Target: SOD3
Purification: Protein G Purified
Specificity: Detects extracellular SOD ~35kDa.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Extracellular Space
Immunogen: Human extracellular SOD purified from aortas
Scientific Background: Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4).There are three types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space (6). SOD3 can also be distinguished by its heparin-binding capacity (1).
Reference: 1. Adachi T., et al. (1992) Clin Chim Acta. 212: 89-102.2. Barrister J.V., et al. (1987). Crit. Rev. Biochem. 22:111-180.3. FurukawaY., and O'Halloran T. (2006) Antioxidants & Redo Signaling. 8(5): 6.4. Gao B., et al. (2003) Am J Physiol Lung Cell Mol Physiol 284: L917-L925.5. Hassan H.M. (1988) Free Radical Biol. Med. 5: 377-385.6. Wispe J.R., et al. (1989) BBA. 994: 30-36.7. Regan, E. et al. (2005) Arthritis & Rheumatism 52(11): 3479–3491

Zusatzinformation

Artikelnummer STRSMC-167D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-167D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Guinea Pig, Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download