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Synaptophysin (native) Antibody: APC/Cy7, Monoclonal

Synaptophysin (native) Antibody: APC/Cy7, Monoclonal
383,94 €
Artikelnummer: STRSMC-178D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Synaptophysin (native) Antibody: APC/Cy7, Monoclonal, Clone: EP10, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human Synaptophysin (native) Monoclonal IgG1
Target: Synaptophysin
Purification: Protein G Purified
Specificity: Detects ~38kDa.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Cytoplasmic Vesicle, Secretory Vesicle, Synaptic Vesicle Membrane, Cell Junction, Synapse
Immunogen: Immunoprecipitate of human brain
Scientific Background: Synaptophysin is a synaptic vesicle glycoprotein with four transmembrane domains weighing 38kDa (1). It is present in neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It acts as a marker for the presynaptic vesicle, and functions in synaptic vesicle exocytosis, including cholesterol-dependent vesicle biogenesis, regulation of SNARE assembly via interaction with VAMP/synaptobrevin, formation of the fusion pore initiating neurotransmitter release, and activation of vesicle endocytosis (2, 3). This gene has also been implicated in X linked mental retardation (4).
Reference: 1. Johnston P.A., et al. (1989) J Biol Chem. 264: 1268-1273.2. Thiele C., et al. (2000) Nat Cell Biol. 2: 42-49.3. Valtorta F., et al. (2004) Bioessays 26: 445-453.4. Tarpey P.S., et al. (2009) Nat Genet. 41(5): 535-543.

Zusatzinformation

Artikelnummer STRSMC-178D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-178D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download