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Syntaxin Antibody: Dylight 488, Monoclonal

Syntaxin Antibody: Dylight 488, Monoclonal
321,36 €
Artikelnummer: STRSMC-181D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Syntaxin Antibody: Dylight 488, Monoclonal, Clone: SP-6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human Syntaxin Monoclonal IgG1
Target: Syntaxin
Purification: Protein G Purified
Specificity: Detects ~38kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Cytoplasmic Vesicle, Secretory Vesicle, Synaptic Vesicle Membrane, Cell Junction, Synapse, Cell Membrane
Immunogen: Raised against synaptic vesicle-containing fractions of immunoprecipitated human brain homogenate
Scientific Background: Syntax ins are a family of membrane integrated Q-SNARE proteins participating in exocytosis (1). They possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. This SNARE domain binds to synaptobrevin and SNAP-25 to form the SNARE complex (2, 3).Support of syntaxin's involvement in vesicular transport and neurotransmission includes the requirement of its yeast homologs, SSO 1 and 2, in targeting and fusion of Golgi-derived vesicles with the plasma membrane (4). Syntaxin also provides the target pf clostridial neurotoxin C1, which blocks neurotransmitter release (5). The formation of 20S complex involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, a-SNAP and NSF (6).
Reference: 1. Bennett M.K., et al. (1993) Cell. 74(5): 863-873.2. Walter A.M., Wiederhold K., Bruns D., Fasshaurer D. and Sorensen J.B. (2010) J Cell BIol. 188(3): 401-413.3. Honma S., Taki K., Lei S., and Wakisaka S. (2010) Anat Rec. Epub.4. Aalto M.K., Ronne H. and Keranen S. (1993) EMBO J. 12: 4095-4104.5. Blasi J., et al. (1993) EMBO J. 12: 4821-4828.6. Sollner T., et al. (1993) Cell. 75: 409-418.

Zusatzinformation

Artikelnummer STRSMC-181D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-181D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download