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Syntaxin Antibody: Dylight 594, Monoclonal

Syntaxin Antibody: Dylight 594, Monoclonal
323,48 €
Artikelnummer: STRSMC-181D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Syntaxin Antibody: Dylight 594, Monoclonal, Clone: SP-6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human Syntaxin Monoclonal IgG1
Target: Syntaxin
Purification: Protein G Purified
Specificity: Detects ~38kDa.
Conjugate: Dylight 594
Immunogen Species: Human
Cellular Location: Cytoplasmic Vesicle, Secretory Vesicle, Synaptic Vesicle Membrane, Cell Junction, Synapse, Cell Membrane
Immunogen: Raised against synaptic vesicle-containing fractions of immunoprecipitated human brain homogenate
Scientific Background: Syntax ins are a family of membrane integrated Q-SNARE proteins participating in exocytosis (1). They possess a single C-terminal transmembrane domain, a SNARE domain, and an N-terminal regulatory domain. This SNARE domain binds to synaptobrevin and SNAP-25 to form the SNARE complex (2, 3).Support of syntaxin's involvement in vesicular transport and neurotransmission includes the requirement of its yeast homologs, SSO 1 and 2, in targeting and fusion of Golgi-derived vesicles with the plasma membrane (4). Syntaxin also provides the target pf clostridial neurotoxin C1, which blocks neurotransmitter release (5). The formation of 20S complex involves the interaction of VAMP with syntaxin through an ATP-dependent reaction modulated by synaptotagmin, SNAP-25, a-SNAP and NSF (6).
Reference: 1. Bennett M.K., et al. (1993) Cell. 74(5): 863-873.2. Walter A.M., Wiederhold K., Bruns D., Fasshaurer D. and Sorensen J.B. (2010) J Cell BIol. 188(3): 401-413.3. Honma S., Taki K., Lei S., and Wakisaka S. (2010) Anat Rec. Epub.4. Aalto M.K., Ronne H. and Keranen S. (1993) EMBO J. 12: 4095-4104.5. Blasi J., et al. (1993) EMBO J. 12: 4821-4828.6. Sollner T., et al. (1993) Cell. 75: 409-418.

Zusatzinformation

Artikelnummer STRSMC-181D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-181D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download