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Tsp23 Antibody: APC/Cy7, Monoclonal

Tsp23 Antibody: APC/Cy7, Monoclonal
416,82 €
Artikelnummer: STRSMC-194D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Tsp23 Antibody: APC/Cy7, Monoclonal, Clone: Tsp232A, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Human Tsp23 Monoclonal IgG1 Kappa
Target: TSP23
Purification: Protein G Purified
Specificity: Detects ~19kDa. Detects Tsp23, no cross-reactivity to p23.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Cytoplasm
Immunogen: Recombinant tsp23
Scientific Background: p23 is a highly conserved ubiquitous protein, known to have an important function as a cochaperone for the HSP90 chaperoning system (1). Studies have revealed that p23 is a small protein (18 to 25 kDa) with a simple structure (2, 3). p23 is a phosphor-protein, which is highly acidic and has an aspartic acid-rich c-terminal domain (1). Numerous studies have found p23 to be associated with other client proteins like Fes tyrosine kinase (4), the heme regulated kinase HRI (5), hsf1 transcription factor (4), aryl hydrocarbon receptor (4), telomerase (6), and Hepadnavirus reverse transcriptase (7). In spite of several years of study, the exact functional significance of p23 is still not clear (8). p23 is thought to be involved in the adenosine triphosphate–mediated HSP90 binding of client proteins (8). Since many HSP90 client proteins are involved in oncogenic survival signaling, a recent study has concluded p23 to be a promising target in leukemic apoptosis (9). HSP90 and its co-chaperone p23 are certainly among the emerging anti-tumor targets in oncology. Specifically TSP23 (transcript similar p23) displays 44% and 17% amino acid identity with p23 and Sba1p respectively (10).
Reference: 1. Johnson J.L., Beito T. G., Krco C.J., Toft D.O. (1994) Mol Cell Biol 14: 1956-63.2. Weikl T., Abelmann K., Buchner J. (1999) J Mol Biol 293: 685-91.3. Weaver A.J., Sullivan W.P., Felts S.J., Owen B.A., Toft D.O. (2000) J Biol Chem 275: 23045-52.4. Nair S.C., et al. (1996) Cell Stress Chaperones 1: 237-50.5. Xu Z., et al. (1997) Eur J Biochem 246, 461-70.6. Holt S.E., et al. (1999) Genes Dev 13: 817-26.7. Hu J., Toft D., Anselmo D., Wang X. (2002) J Virol 76: 269-79.8. Felts, S.J., Toft D.O. (2003) Cell Stress Chaperones.8: 108-13.9. Gausdal G., Gjertsen B.T., Fladmark K.E., Demol H., Vandekerckhove J. & Doskeland S.O. (2004) Leukemia10. Freeman B.C., Felts S.J., Toft D.O., Yamamato K.R. (2000) Genes Dev. 14(4): 433-434.

Zusatzinformation

Artikelnummer STRSMC-194D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-194D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download