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Grp75 Antibody: Dylight 594, Monoclonal

Grp75 Antibody: Dylight 594, Monoclonal
352,12 €
Artikelnummer: STRSMC-133D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Grp75 Antibody: Dylight 594, Monoclonal, Clone: S52A-42, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Mouse Grp75 Monoclonal IgG1
Target: GRP75
Purification: Protein G Purified
Specificity: Detects ~75kDa.
Conjugate: Dylight 594
Immunogen Species: Mouse
Cellular Location: Mitochondrion
Immunogen: Fusion protein amino acids 551-766 of mouse SALM2.
Scientific Background: Grp75, also known as mortalin, is a member of HSP70 family of chaperone proteins that is not heat inducible (1, 2). Grp75 is actually induced under conditions of low glucose and other nutritional and environmental stresses. Grp75 resides primarily in the mitochondrial matrix, where it collaborates with HSP60 in the re-folding of proteins translocated into this organelle (3, 4). Related forms may also be found in the cytosol or on the surface of the extracellular membrane.Other Grp75 functions include its ability to inactivate the tumor suppressor p53 (5). Studies have found that Grp75 is over-expressed in many tumor tissues and immortalized human cell lines, suggesting its role in the tumor formation (6). Grp75 is also implicated in cell aging, as its overexpression appears to prolong the life span of human fibroblasts (7). And finally, like its E.coli homolog DnaK (8), GRP75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone (9, 10).
Reference: 1. Kaul S.C., et al. (1993) Biochem Biophys Res Commun. 193: 348-355.2. Wadhwa R., et al. (1993) J Biol Chem 268: 6615-6621.3. Schneider H.C., et al. (1994) Nature 371: 768-774.4. Manning-Krieg U.C., et al. (1991) EMBO J. 10: 3273-3280.5. Wadhwa R., et al. (1998) J Biol Chem. 273: 29586-91.6. Wadhwa R., et al. (2006) Int J Cancer 118: 2973-2980.7. Kaul S.C., et al. (2003) Exp Cell Res. 286: 96-110.8. Liberek K., et al. (1991) J Biol Chem. 266: 14491-14496.9. Mizzen L.A., et al. (1991) Cell Regulation. 2: 165-179.10. Leustek U.K., et al. (1989) PNAS USA. 86: 7805-7808.

Zusatzinformation

Artikelnummer STRSMC-133D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-133D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Caenorhabditis Elegans, Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download