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HIF1 alpha Antibody: APC/Cy7, Monoclonal

HIF1 alpha Antibody: APC/Cy7, Monoclonal
406,21 €
Artikelnummer: STRSMC-184D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
HIF1 alpha Antibody: APC/Cy7, Monoclonal, Clone: ESEE122, Host: Mouse, Isotype: IgG1


Mouse Anti-Mouse HIF1 alpha Monoclonal IgG1
Target: HIF 1 alpha
Purification: Protein G Purified
Specificity: Detects ~116kDa. Specific for HIF1Alpha.
Conjugate: APC/Cy7
Immunogen Species: Mouse
Cellular Location: Cytoplasm, Nucleus
Immunogen: Recombinant fragment corresponding to amino acids 329-530
Scientific Background: Hypoxia-inducible factor 1 (HIF1) is a heterodimeric transcription factor that plays a critical role in the cellular response of hypoxia (1). The HIF1 complex consists of two subunits, HIF1-Alpha and HIF1-Beta, which are basic helix-loop-helix proteins of the PAS family (2). HIF1 regulates the transcription of a broad range of genes that facilitate responses to the hypoxic environment, including genes regulating angiogenesis, erythropoiesis, cell cycle, metabolism and apoptosis. The widely expressed HIF-1α is typically degraded rapidly in normoxic cells by the ubiquitin/proteasomal pathway. Under normoxic conditions, HIF-1α is proline hydroxylated leading to a conformational change that promotes binding to the von Hippel Lindau protein (VLH) E3 ligase complex; ubiquitination and proteasomal degradation follows (3, 4). Both hypoxic conditions and chemical hydroxylase inhibitors (such as desferrioxamine and cobalt) inhibit HIF-1α degradation and lead to its stabilization. In addition, HIF-1α can be induced in an oxygen-independent manner by various cytokines through the PI3K-AKT-mTOR pathway (5-7).
Reference: 1. Sharp F.R. and Bernaudin M. (2004) Nat Rev Neurosci 5: 437-48.2. Wang G.L., et al. (1995) Proc Natl Acad Sci U S A 92: 5510-4.3. Jaakkola P., et al. (2001) Science 292: 468-72.4. Maxwell P.H., et al. (1999) Nature 399: 271-5.5. Fukuda R., et al. (2002) J Biol Chem 277: 38205-11.6. Jiang B.H., et al. (2001) Cell Growth Differ 12: 363-9.7. Laughner E., et al. (2001) Mol Cell Biol 21: 3995-4004.


Artikelnummer STRSMC-184D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-184D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download