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MDC1 Antibody: Dylight 405, Monoclonal

MDC1 Antibody: Dylight 405, Monoclonal
342,58 €
Artikelnummer: STRSMC-197D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
MDC1 Antibody: Dylight 405, Monoclonal, Clone: P2B11, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Mouse MDC1 Monoclonal IgG1
Target: MDC1
Purification: Protein G Purified
Specificity: Detects ~184kDa. This antibody recognizes MDC1 at and around the N-terminus.
Conjugate: Dylight 405
Immunogen Species: Mouse
Cellular Location: Nucleus
Immunogen: GST-tagged recombinant protein corresponding to mouse MDC1 at and around the N-terminus
Scientific Background: MDC1, mediator of DNA damage checkpoint protein 1, plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, within S phase and G2/M. It is also thought to act as a scaffold protein during recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139.
Reference: 1. Lou Z., et al. (2004) J Biol Chem. 279(45): 46359-46362.2. Luo K., Yuan J, Lou Z. (2011) J Biol Chem. 286(32): 28192-28199.3. Strauss C., Halevy T., Macarov M., Argaman L., and Goldbery M. (2011) DNA Repair (Amst.). 10(8): 806-814.4. Wilson K.A., et al. (2011) Mol Cancer Res. 9(6): 766-781.

Zusatzinformation

Artikelnummer STRSMC-197D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-197D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Chimpanzee (Primate), Cow (Bovine), Human, Mouse (Murine)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download