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Piccolo Antibody: Dylight 633, Monoclonal

Piccolo Antibody: Dylight 633, Monoclonal
344,70 €
Artikelnummer: STRSMC-188D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Piccolo Antibody: Dylight 633, Monoclonal, Clone: 6H9-B6, Host: Mouse, Isotype: IgG2b

Details

Mouse Anti-Mouse Piccolo Monoclonal IgG2b Kappa
Target: Piccolo
Purification: Protein G Purified
Specificity: Detects ~550kDa. No cross-reactivity to Bassoon.
Conjugate: Dylight 633
Immunogen Species: Mouse
Cellular Location: Cell Junction, Synapse
Immunogen: Full length recombinant protein (GenBank ID: BC001304.1)
Scientific Background: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2+ finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).
Reference: 1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619.2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162.3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038-6047.

Zusatzinformation

Artikelnummer STRSMC-188D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-188D-DY633
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG2
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download