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Nitrotyrosine Antibody: APC/Cy7, Monoclonal

Nitrotyrosine Antibody: APC/Cy7, Monoclonal
451,82 €
Artikelnummer: STRSMC-154D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Nitrotyrosine Antibody: APC/Cy7, Monoclonal, Clone: 39B6, Host: Mouse, Isotype: IgG2a

Details

Mouse Anti- Nitrotyrosine Monoclonal IgG2a
Target: Nitrotyrosine
Purification: Protein G Purified
Specificity: Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.
Conjugate: APC/Cy7
Immunogen: 3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin
Scientific Background: Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase.Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).
Reference: 1. Girault I. et al. (2001). Free Radical Biology and Medicine, 31 (11): 1375-1387.2. Gow AJ, Farkouh CR, Munson DA, Posencheq MA, and Ischiropoulos H. (2004). Am J Physiol Lung Cell Mol Physiol. 287(2): L262-8.3. Takemoto K. et al (2007). Acta Med Okayama 61(1): 17-30.4. Reynolds MR. et al. (2006) J Nerosci. 26(42): 10636-45.5. Pfister H., et al. (2002) Vet Pathol. 39: 190-199.6. Khan J. et al. (1998) Biochem J. 330(2): 795-801.

Zusatzinformation

Artikelnummer STRSMC-154D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-154D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Various species
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG2
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download