• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

Nitrotyrosine Antibody: Dylight 633, Monoclonal

Nitrotyrosine Antibody: Dylight 633, Monoclonal
363,79 €
Artikelnummer: STRSMC-154D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Nitrotyrosine Antibody: Dylight 633, Monoclonal, Clone: 39B6, Host: Mouse, Isotype: IgG2a

Details

Mouse Anti- Nitrotyrosine Monoclonal IgG2a
Target: Nitrotyrosine
Purification: Protein G Purified
Specificity: Recognizes 3-nitrotyrosine moieties. No detectable cross-reactivity with non-nitrated tyrosine. Not species specific.
Conjugate: Dylight 633
Immunogen: 3-(4-hydroxy-3-nitrophenylacetamido) propionic acid-bovine serum albumin
Scientific Background: Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosino-philperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase.Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).
Reference: 1. Girault I. et al. (2001). Free Radical Biology and Medicine, 31 (11): 1375-1387.2. Gow AJ, Farkouh CR, Munson DA, Posencheq MA, and Ischiropoulos H. (2004). Am J Physiol Lung Cell Mol Physiol. 287(2): L262-8.3. Takemoto K. et al (2007). Acta Med Okayama 61(1): 17-30.4. Reynolds MR. et al. (2006) J Nerosci. 26(42): 10636-45.5. Pfister H., et al. (2002) Vet Pathol. 39: 190-199.6. Khan J. et al. (1998) Biochem J. 330(2): 795-801.

Zusatzinformation

Artikelnummer STRSMC-154D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-154D-DY633
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Various species
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG2
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download