• Sie sehen derzeit Listenpreise. Um Ihren Vorteilspreis zu sehen, melden Sie sich mit Ihrem Kundenkonto an.

Phosphothreonine Antibody: Dylight 633, Monoclonal

Phosphothreonine Antibody: Dylight 633, Monoclonal
318,18 €
Artikelnummer: STRSMC-158D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
Phosphothreonine Antibody: Dylight 633, Monoclonal, Clone: 18F6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti- Phosphothreonine Monoclonal IgG1 Kappa
Target: Phosphothreonine
Purification: Ascites
Specificity: Reacts with phosphothreonine, and detects the presence of phosphothreonine in proteins of both un-stimulated and stimulated cell lysates. Does not cross-react with phosphoserine or phosphotyrosine.
Conjugate: Dylight 633
Immunogen: Phosphothreonine conjugated to KLH
Scientific Background: Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (1). Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (2-4).
Reference: 1. Goto H. et al. (2005) Nature Cell Biology 8: 180-187.2. Blume-Jensen P. and Hunter T. (2001) Nature 411:355-365.3. Downward J. (2001) Nature 411: 759-762.4. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678.5. Frackelton A.R. Jr., Ross A.H., and Eisen H.N. (1983) Mol Cell Biol. 3: 1343-1352.6. Ross A.H., Baltimore D., and Eisen H.N. (1981) Nature 294: 654-656.7. Ostrovsky PC. (1995) Genes Dev. 9(16): 2034-2041.

Zusatzinformation

Artikelnummer STRSMC-158D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-158D-DY633
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Various species
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download