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Phosphotyrosine Antibody: Dylight 405, Monoclonal

Phosphotyrosine Antibody: Dylight 405, Monoclonal
353,18 €
Artikelnummer: STRSMC-174D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Phosphotyrosine Antibody: Dylight 405, Monoclonal, Clone: G104, Host: Mouse, Isotype: IgG1

Details

Mouse Anti- Phosphotyrosine Monoclonal IgG1
Target: Phosphotyrosine
Purification: Protein G Purified
Specificity: Reacts with phosphotyrosine, and detects the presence of phosphotyrosine in both un-stimulated and stimulated cell lysates. Does not cross-react with phosphoserine or phosphothreonine.
Conjugate: Dylight 405
Immunogen: Phosphotyrosine, alanine and glyceine in a 1:1:1 ratio polymerized in the presence of keyhole limpet hemocyanin with 1-ethyl-3-(3'-dimentrylaminopropyl) carbodiimide
Scientific Background: Protein phosphorylation is an important posttranslational modification that serves many key functions to regulate a protein's activity, localization, and protein-protein interactions. Phosphorylation is catalyzed by various specific protein kinases, which involves removing a phosphate group from ATP and covalently attaching it to to a recipient protein that acts as a substrate. Most kinases act on both serine and threonine; others act on tyrosine, and a number (dual specificity kinases) act on all three. Because phosphorylation can occur at multiple sites on any given protein, it can therefore change the function or localization of that protein at any time (3). Changing the function of these proteins has been linked to a number of diseases, including cancer, diabetes, heart disease, inflammation and neurological disorders (4-6).In particular, the phosphorylation of tyrosine is considered one of the key steps in signal transduction and regulation of enzymatic activity (7). Phosphotyrosine can be detected through specific antibodies, and are helpful in facilitating the identification of tyrosine kinase substrates (8).
Reference: 1. Garton A.J., Flint A.J., and Tonks N.K. (1996) Mol and Cell Bio 16(11): 6408-6418.2. Garton A.J., and Tonks N.K. (1999) J Bio Chem. 274(6): 3811-3818.3. Goto H. et al. (2005) Nature Cell Biology 8: 180-187.4. Blume-Jensen P. and Hunter T. (2001) Nature 411: 355-365.5. Downward J. (2001) Nature 411: 759-762.6. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678.7. Frackelton A.R. Jr., Ross A.H., and Eisen H.N. (1983) Mol Cell Biol. 3: 1343-1352.8. Ross A.H., Baltimore D., and Eisen H.N. (1981) Nature 294: 654-656.9. Tiganis T., Kemp B.E., and Tonks N.K. (1999) J. Bio Chem. 274(39): 27768-27775.

Zusatzinformation

Artikelnummer STRSMC-174D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SMC-174D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Various species
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download