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ENaC alpha Antibody: Dylight 488, Monoclonal

ENaC alpha Antibody: Dylight 488, Monoclonal
355,30 €
Artikelnummer: STRSMC-242D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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ENaC alpha Antibody: Dylight 488, Monoclonal, Clone: 14E10, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Rat ENaC alpha Monoclonal IgG1
Target: ENaC alpha
Purification: Protein G Purified
Specificity: Detects ~85kDa.
Conjugate: Dylight 488
Immunogen Species: Rat
Cellular Location: Apical Cell Membrane
Immunogen: Synthetic peptide from the N-terminal of Rat ENaC alpha (aa. 46-68)
Scientific Background: The Epithelial Sodium Channel (ENaC) is a membrane ion channel permeable to Na+ ions. It is located in the apical plasma membrane of epithelia in the kidneys, lung, colon, and other tissues where it plays a role in trans epithelial Na+-ion transport (1). Specifically Na+ transport via ENaC occurs across many epithelial surfaces, and plays a key role in regulating salt and water absorption (2).ENaCs are composed of three structurally related subunits that form a tetrameric channel, alpha, beta, and gamma. The expression of its alpha and beta subunits is enhanced as keratinocytes differentiate (3, 4). The beta and gamma-ENaC subunits are essential for edema fluid to exert its maximal effect on net fluid absorption by distal lung epithelia(5). And it has been concluded that the subunits are differentially expressed in the retina of mice with ocular hypertension, therefore the up-regulation of alpha-ENaC proteins could serve as a protection mechanism against elevated intraocular pressure (6).
Reference: 1. Kakizoe Y., et al. (2009) J Hpyertens. 27(8): 1679-1689.2. Gu Y. (2008) J Cell Physiol. 216(2):453-457.3. Bruns J.B. (2003) Am J Physiol Renal Physiol. 285(4): F600-F609.4. Mauro T., et al. (2002) J Invest Dermatol. 118(4): 589-594.5. Elias N., et al. (2007) Am J Physiol Lung Cell Mol Physiol. 293(3): L537-45.6. Dyka F.M., May C.A. and Enz R. (2005) J Neurochem. 94(1): 120-128.

Zusatzinformation

Artikelnummer STRSMC-242D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SMC-242D-DY488
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunohistochemistry, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download