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PSD95 Antibody: Dylight 594, Monoclonal

PSD95 Antibody: Dylight 594, Monoclonal
334,09 €
Artikelnummer: STRSMC-122D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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PSD95 Antibody: Dylight 594, Monoclonal, Clone: 6G6, Host: Mouse, Isotype: IgG2a

Details

Mouse Anti-Rat PSD95 Monoclonal IgG2a
Target: PSD95
Purification: Protein G Purified
Specificity: Detects ~100kDa. An additional protein of >100kDa is also detected. Additional cross-reactive bands are detected at ~75kDa and 50kDa in rat and mouse samples.
Conjugate: Dylight 594
Immunogen Species: Rat
Cellular Location: Cell Membrane, Cell Junction, Synapse, Postsynaptic Cell Membrane, Postsynaptic Density, Cell Projection, Axon
Immunogen: Recombinant rat PSD-95
Scientific Background: Postsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex (1). These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins (2). Thus different PDZ domains of PSD-95 might be specialized for distinct functions (3, 4).PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) (5). The protein is implicated in experience dependent plasticity and plays an indispensable role in learning (6). Mutations in PSD95 are associated with autism (7).
Reference: 1. Chetkovich D.M., Bunn R.C., Kuo S.H., Kawasaki Y., Kohwi M., and Bredt D.S. (2002) J Neurosci. 22(15): 6415-25.2. Cao J., Viholainen J.I., Dart C., Warwick H.K., Levland M.L. and Courtney M.J. (2005) J Cell Biol. 168(1): 117-26.3. Kennedy M. (1997) Trends in Neurosci. 6: 264-268.4. Irie M. et al. (1997) Science 277(5331): 1511-5.5. Cai C. et al. (2006) J Biol Chem. 281: 4267-73.6. Yao W.D. et al. (2004) Neuron 41: 625-38.7. Cline H. (2005) Curr Biol. 15: R203-5.

Zusatzinformation

Artikelnummer STRSMC-122D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-122D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Cow (Bovine), Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blotting
Isotype IgG2
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download