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SAP102 Antibody: Dylight 594, Monoclonal

SAP102 Antibody: Dylight 594, Monoclonal
291,67 €
Artikelnummer: STRSMC-134D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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SAP102 Antibody: Dylight 594, Monoclonal, Clone: S19-2, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Rat SAP102 Monoclonal IgG1
Target: SAP102
Purification: Protein G Purified
Specificity: Detects ~105kDa. No cross-reactivity against PSD95, SAP97 or Chapsyn-110.
Conjugate: Dylight 594
Immunogen Species: Rat
Cellular Location: Basolateral Cell Membrane, Cytoplasm, Cell Junction, Synapse, Postsynaptic Cell Membrane, Postsynaptic Density, Growth Cone
Immunogen: Fusion protein amino acids 1-120 of rat SAP102
Scientific Background: Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal (1, 2). SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homology 3 domain and a guanylate kinase domain (3). All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway (3, 4). SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains (3). In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.
Reference: 1. Muller B.M., et al. (1996) Neuron 17: 255-265.2. Lau L. F., et al. (1996) J. Biol. Chem. 271: 21622-21628.3. Cuthbert P.C., et al. (2007) J Neuroscience 27:2673-2682.4. Lau L.F., et al. (1996) J Biol Chem 274:5782-5790.

Zusatzinformation

Artikelnummer STRSMC-134D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SMC-134D-DY594
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download