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HSP90 Antibody: Dylight 633, Monoclonal

HSP90 Antibody: Dylight 633, Monoclonal
405,15 €
Artikelnummer: STRSMC-112B-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
HSP90 Antibody: Dylight 633, Monoclonal, Clone: AC-16, Host: Mouse, Isotype: IgG2b

Details

Mouse Anti-Water Mold HSP90 Monoclonal IgG2b
Target: HSP90
Purification: Protein G Purified
Specificity: Detects 90kDa. This antibody is reactive with both the constitutive and the inducible form of HSP90. It does not bind to the native form and does not recognize HSP90 from E.coli or yeast.
Conjugate: Dylight 633
Immunogen Species: Water Mold
Cellular Location: Cytoplasm, Melanosome
Immunogen: Heat shock protein 90 from the water mold Achyla ambisexualis
Scientific Background: HSP90 is a highly conserved and essential stress protein that is expressed in all eukaryotic cells. From a functional perspective, HSP90 participates in the folding, assembly, maturation, and stabilization of specific proteins as an integral component of a chaperone complex (1-4). Despite its label of being a heat-shock protein, HSP90 is one of the most highly expressed proteins in unstressed cells (1–2% of cytosolic protein). It carries out a number of housekeeping functions – including controlling the activity, turnover, and trafficking of a variety of proteins. Most of the HSP90-regulated proteins that have been discovered to date are involved in cell signaling (5-6). The number of proteins now know to interact with HSP90 is about 100. Target proteins include the kinases v-Src, Wee1, and c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of the hepatitis B virus and telomerase (5). When bound to ATP, HSP90 interacts with co-chaperones Cdc37, p23, and an assortment of immunophilin-like proteins, forming a complex that stabilizes and protects target proteins from proteasomal degradation.In most cases, HSP90-interacting proteins have been shown to co-precipitate with HSP90 when carrying out immuno-adsorption studies, and to exist in cytosolic heterocomplexes with it. In a number of cases, variations in HSP90 expression or HSP90 mutation has been shown to degrade signaling function via the protein or to impair a specific function of the protein (such as steroid binding, kinase activity) in vivo. Ansamycin antibiotics, such as geldanamycin and radicicol, inhibit HSP90 function (7).
Reference: 1. Arlander SJH, et al. (2003) J Biol Chem 278: 52572-52577.2. Pearl H, et al. (2001) Adv Protein Chem 59:157-186.3. Neckers L, et al. (2002) Trends Mol Med 8:S55-S61.4. Pratt W, Toft D. (2003) Exp Biol Med 228:111-133.5. Pratt W, Toft D. (1997) Endocr Rev 18: 306–360.6. Pratt WB. (1998) Proc Soc Exptl Biol Med 217: 420–434.7. Whitesell L, et al. (1994) Proc Natl Acad Sci USA 91: 8324–8328.

Zusatzinformation

Artikelnummer STRSMC-112B-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-112B-DY633
Verpackungseinheit 200 µg
Mengeneinheit FL
Reaktivität Chicken, Fungi, Human, Insect, Mouse (Murine), Plant, Rabbit, Rat (Rattus)
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunohistochemistry, Western Blotting
Isotype IgG2
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download