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HDEL Antibody: Dylight 350, Monoclonal

HDEL Antibody: Dylight 350, Monoclonal
388,18 €
Artikelnummer: STRSMC-175D-DY350

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
HDEL Antibody: Dylight 350, Monoclonal, Clone: 2E7, Host: Mouse, Isotype: IgG2b

Details

Mouse Anti-Yeast HDEL Monoclonal IgG2b
Target: HDEL
Purification: Protein G Purified
Specificity: Detects ~78kDa.
Conjugate: Dylight 350
Immunogen Species: Yeast
Cellular Location: Endoplasmic Reticulum
Immunogen: Raised against a synthetic HDEL peptide corresponding to the C-terminus of yeast Bip
Scientific Background: HSP 70 family comprises four highly conserved proteins, HSP 70, HSC 70, GRP 75 and GRP 78, which serve a variety of roles. They act as molecular chaperones, facilitating the assembly of multi-protein complexes; participate in the translocation of polypeptides across cell membranes and to the nucleus; and aid in the proper folding of nascent polypeptide chains (1, 2). GRP 78 is localized in the endoplasmic reticulum (ER), where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains (2). Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually KDEL in animal cells, and HDEL in S.cerevisiae (3). The 2E7 clone recognizes the C-terminal peptide HDEL, a common version of the endoplasmic reticulum retention signal found in yeast, plant, nematode and other ER proteins. 2E7 specifically stains HDEL proteins in barnyard grass, beet, cotton, mung bean, sorghum and wheat (4).
Reference: 1. Mayer M.P., and Bukau B. (2005) Cell Mol Life Sci. 62(6): 670-684.2. Luo S., Mao C., Lee B., and Lee A.S. (2006) Mol Cell Biol. 26(15): 5688-5697.3. Entrez Gene: HDEL, Gene ID: 109454. Napier R.M., et al. (1992) J Cell Sci. 102: 261-271.

Zusatzinformation

Artikelnummer STRSMC-175D-DY350
Hersteller Stressmarq Biosciences
Herstellernummer SMC-175D-DY350
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Fruit Fly (Drosophila Melanogaster), Plant, Yeast
Klonalität Monoclonal
Wirt / Host Mouse
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype IgG2
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Download