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HSP40, YDJ1 Antibody: APC/Cy7, Monoclonal

HSP40, YDJ1 Antibody: APC/Cy7, Monoclonal
432,73 €
Artikelnummer: STRSMC-150D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
HSP40, YDJ1 Antibody: APC/Cy7, Monoclonal, Clone: 1G10.H8, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Yeast HSP40, YDJ1 Monoclonal IgG1 Kappa
Target: HSP40
Purification: Protein G Purified
Specificity: Detects ~40kDa. Yeast specific product. Does not cross react with Human, Mouse or Rat.
Conjugate: APC/Cy7
Immunogen Species: Yeast
Cellular Location: Cytoplasm, Nucleus
Immunogen: Full length protein yeast HSP40 (YDJ1)
Scientific Background: Human HSP40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein) (1). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain (2). There are two main types of HSP40; type 1 DNAJ proteins including HDJ2 and yeast YdjI; type II includes yeast Sis1 and human Hdj1. Whereas type I possesses a zinc finger domain which helps in the function of protein folding. (3, 4), type II does not.Members of the HSP40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation, degradation and assembly of multi-protein complexes. HSP40 stimulates the ATPase activity of HSP70 which in turn causes conformational changes of the unfolded proteins (5, 6). The HSP40-HSP70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1 (7).
Reference: 1. Cheetham M.E. and Caplan A.J. (1998) Cell Stress Chaperones 3: 28–36.2. Fan C.Y., et al. (2003) Cell Stress Chaperones 8: 309–316.3. Terda K., et al. (1997) J Cell Biol. 139: 1089-1095.4. Lu Z. and Cyr D.M. (1998) J Biol Chem. 273: 27824-27830.5. Liberek K. et al. (1991) Proc. Natl. Acad. Sci. USA 88: 2874–2878.6. Cyr D.M., et al. (1992) J Biol Chem. 267: 20927–20931.7. Höhfeld J., et al. (2001) EMBO Rep. 2: 885–890.

Zusatzinformation

Artikelnummer STRSMC-150D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SMC-150D-APCCY7
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Yeast
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download