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HSP40, YDJ1 Antibody: Dylight 633, Monoclonal

HSP40, YDJ1 Antibody: Dylight 633, Monoclonal
344,70 €
Artikelnummer: STRSMC-166D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

Kostenlose Lieferung innerhalb Österreichs!
HSP40, YDJ1 Antibody: Dylight 633, Monoclonal, Clone: 2A7.H6, Host: Mouse, Isotype: IgG1

Details

Mouse Anti-Yeast HSP40, YDJ1 Monoclonal IgG1 Kappa
Target: HSP40
Purification: Protein G Purified
Specificity: Detects ~40kDa. Yeast specific. Does not cross react with Human, Mouse or Rat.
Conjugate: Dylight 633
Immunogen Species: Yeast
Cellular Location: Cytoplasm, Nucleus
Immunogen: Full length protein HSP40 (YDJ1)
Scientific Background: Human HSP40/DnaJ proteins comprise a large protein family, members of which feature the J domain (named after the bacterial DnaJ protein) (1). The J-domain spans the first 75 N-terminal amino acids and is separated from the C-terminal by a glycine/phenylalanine-rich domain (2). Members of the HSP40/DnaJ family play diverse roles in many cellular processes, such as folding, translocation, degradation and assembly of multi-protein complexes. In particular, Hdj1, the first human HSP40/DnaJ protein identified, plays an important role in protein translation and folding, as well as in the regulation of HSP70 function (3). HSP40 stimulates the ATPase activity of HSP70 which in turn causes conformational changes of the unfolded proteins (4, 5). The HSP40-HSP70-unfolded protein complex further binds to co-chaperones Hip, Hop and HSP90 which leads to protein folding, or components of protein degradation machinery CHIP and BAG-1 (6). Some studies have shown that the difference between HDJ1 and type 1 DNAJ proteins including HDJ2 and yeast YdjI is the result of the possession of a zinc finger domain by the latter, which helps in the function of protein folding. (7, 8).
Reference: 1. Cheetham M.E. and Caplan A.J. (1998) Cell Stress Chaperones 3: 28–36.2. Fan C.Y., et al. (2003) Cell Stress Chaperones 8: 309–316.3. Sohn S.Y., Kim S.B., Kim J., and Ahn B.Y. (2006) J Gen Virol. 87(7): 1883-91.4. Liberek K. et al. (1991) Proc. Natl. Acad. Sci. USA 88: 2874–2878.5. Cyr D.M., et al. (1992) J Biol Chem. 267: 20927–20931.6. Höhfeld J., et al. (2001) EMBO Rep. 2: 885–890.7. Terda K., et al. (1997) J Cell Biol. 139: 1089-1095.8. Lu Z. and Cyr D.M. (1998) J Biol Chem. 273: 27824-27830.

Zusatzinformation

Artikelnummer STRSMC-166D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SMC-166D-DY633
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Yeast
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunoprecipitation, Western Blotting
Isotype IgG1
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download