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Abl1 Antibody (pTyr226): Dylight 594, Polyclonal

Abl1 Antibody (pTyr226): Dylight 594, Polyclonal
401,97 €
Artikelnummer: STRSPC-902D-DY594

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Abl1 Antibody (pTyr226): Dylight 594, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Abl1 (pTyr226) Polyclonal
Target: Abl1 (pTyr226)
Purification: Peptide Affinity Purified
Specificity: Detects 122.945 kDa.
Tissue Specificity: Widely expressed
Conjugate: Dylight 594
Immunogen Species: Human
Cellular Location: Cytoplasm, Cytoskeleton, Nucleus, Mitochondrion
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr226 of human Abl1 (AA223-229)
Scientific Background: ABL1 is a widely-expressed, non-receptor protein-tyrosine kinase. It is stabilized in the inactive form by an association between the SH3 domain and the SH2-TK linker region, interactions of the N-terminal cap, and contributions from an N-terminal myristoyl group and phospholipids. It is activated by autophosphorylation as well as by Src-family kinase-mediated phosphorylation. It can also be activated by RIN1 binding to the SH2 and SH3 domains. As it is stimulated by cell death inducers and DNA-damage, it is likely that the wild-type form of Abl1 is actually a tumour -suppressor protein. The normal active form of Abl1 is nuclear, and it is sequestered into the cytoplasm by interaction with 14-3-3 through Thr-735. It localizes to the mitochondria under conditions of oxidative stress.

Zusatzinformation

Artikelnummer STRSPC-902D-DY594
Hersteller Stressmarq Biosciences
Herstellernummer SPC-902D-DY594
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download