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Alpha Synuclein Antibody: Dylight 405, Polyclonal

Alpha Synuclein Antibody: Dylight 405, Polyclonal
364,85 €
Artikelnummer: STRSPC-800D-DY405

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Alpha Synuclein Antibody: Dylight 405, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Alpha Synuclein Polyclonal
Target: Alpha Synuclein
Purification: Protein A Purified
Specificity: Detects ~14.46kda.
Tissue Specificity: Highly expressed in brain (presynaptic nerve terminals) but is also expressed in low concentrations in all tissues examined except in liver.
Conjugate: Dylight 405
Immunogen Species: Human
Cellular Location: Cytoplasm, Membrane, Nucleus, Cell Junction, Synapse, Secreted
Immunogen: Synthetic peptide from the full length of Human Alpha Synuclein
Scientific Background: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).
Reference: 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

Zusatzinformation

Artikelnummer STRSPC-800D-DY405
Hersteller Stressmarq Biosciences
Herstellernummer SPC-800D-DY405
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine), Rat (Rattus)
Klonalität Polyclonal
Wirt / Host Rabbit
Methode ELISA, Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download