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Annexin A1 Antibody (pTyr207): Dylight 350, Polyclonal

Annexin A1 Antibody (pTyr207): Dylight 350, Polyclonal
444,39 €
Artikelnummer: STRSPC-916D-DY350

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Annexin A1 Antibody (pTyr207): Dylight 350, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Annexin A1 (pTyr207) Polyclonal
Target: Annexin A1 (pTyr207)
Purification: Peptide Affinity Purified
Specificity: Detects 38.714 kDa.
Tissue Specificity: Detected in resting neutrophils, peripheral blood T-cells, placenta, liver.
Conjugate: Dylight 350
Immunogen Species: Human
Cellular Location: Nucleus, Cytoplasm, Basolateral Cell Membrane
Immunogen: A phospho-specific peptide corresponding to residues surrounding Tyr207 of human Annexin A1 (AA204-210)
Scientific Background: Annexin A2 (ANXA2), also known as Annexin II and Lipocortin II (LPC2), is a 38.6 kDa member of the Annexin family of proteins. The Annexins are a family of Calcium-dependent phospholipid-binding proteins that are preferentially located on the cytosolic face of the plasma membrane. The Annexin's have a molecular weight of approximately 35‑40 kDa and consist of a unique amino terminal domain followed by a homologous C-terminal core domain containing the calcium-dependent phospholipid-binding sites. The C-terminal domain is comprised of four 60‑70 amino acid (aa) repeats, known as annexin repeats or an endonexin fold (Annexin A6 contains 8 annexin repeats). The four annexin repeats form a highly alpha -helical, tightly packed disc known as the annexin domain, which binds to phospholipids in the membrane in a calcium-dependent manner. Members of the annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways. Annexin A2 was identified as an inhibitor of phospholipase A2 activity. Annexin A2 also functions as an autocrine factor to enhance osteoclast formation and bone resorption and is a major cellular substrate of the tyrosine kinase encoded by the SRC oncogene. Human Annexin A2 shares 97% identity with mouse and rat Annexin A2.

Zusatzinformation

Artikelnummer STRSPC-916D-DY350
Hersteller Stressmarq Biosciences
Herstellernummer SPC-916D-DY350
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download