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Aurora A Antibody (pThr287 + pThr288): APC/Cy7, Polyclonal

Aurora A Antibody (pThr287 + pThr288): APC/Cy7, Polyclonal
440,15 €
Artikelnummer: STRSPC-919D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Aurora A Antibody (pThr287 + pThr288): APC/Cy7, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Aurora A (pThr287 + pThr288) Polyclonal
Target: Aurora A (pThr287 + pThr288)
Purification: Peptide Affinity Purified
Specificity: Detects ~48kDa.
Tissue Specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Cytoplasm, Cytoskeleton
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr287 and Thr288 of human Aurora A (AA285-291)
Scientific Background: Aurora A is part of the larger AURA family of serine/threonine kinases and is a key regulator of mitotic cell division. It is involved in regulating microtubule formation and the assembly of the mitotic spindle responsible for chromosome segragation during mitosis. AURA activity is cell cycle dependent with the greatest activity occuring during mitosis. The overexpression of AURA has been well documented in many malignant cancers including breast, ovarian, colon, prostate and neuroblastomas. Overexpression of AURA appears to override checkpoints in cell cycle progression leading to increased cell division and proliferation.

Zusatzinformation

Artikelnummer STRSPC-919D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SPC-919D-APCCY7
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download