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Aurora B Antibody (pSer227): Dylight 350, Polyclonal

Aurora B Antibody (pSer227): Dylight 350, Polyclonal
444,39 €
Artikelnummer: STRSPC-920D-DY350

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Aurora B Antibody (pSer227): Dylight 350, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Aurora B (pSer227) Polyclonal
Target: Aurora B (pSer227)
Purification: Peptide Affinity Purified
Specificity: Detects 39.28 kDa.
Tissue Specificity: High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase
Conjugate: Dylight 350
Immunogen Species: Human
Cellular Location: Nucleus, Cytoplasm, Cytoskeleton
Immunogen: A phospho-specific peptide corresponding to residues surrounding Ser227 of human Aurora B (AA222-228)
Scientific Background: Aurora B is part of the larger AURA family of serine/threonine kinases and is a key regulator of mitotic cell division. It is involved in regulating microtubule formation and the assembly of the mitotic spindle responsible for chromosome segragation during mitosis. AURA activity is cell cycle dependent with the greatest activity occuring during mitosis. The overexpression of AURA has been well documented in many malignant cancers including breast, ovarian, colon, prostate and neuroblastomas. Overexpression of AURA appears to override checkpoints in cell cycle progression leading to increased cell division and proliferation.

Zusatzinformation

Artikelnummer STRSPC-920D-DY350
Hersteller Stressmarq Biosciences
Herstellernummer SPC-920D-DY350
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download