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CaMKII Antibody (pThr286): Dylight 488, Polyclonal

CaMKII Antibody (pThr286): Dylight 488, Polyclonal
397,73 €
Artikelnummer: STRSPC-931D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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CaMKII Antibody (pThr286): Dylight 488, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human CaMKII (pThr286) Polyclonal
Target: CaMKII (pThr286)
Purification: Peptide Affinity Purified
Specificity: Detects 54.03 kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Cell Junctions, Synapse, Presynaptic Cell Membrane
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr286 of human CaMKII (AA282-289)
Scientific Background: CaMKII is an important member of calcium/calmodulin- activated protein kinase family, functioning in neural synaptic stimulation and T-cell receptor signaling (1, 2). CaMKII is expressed in many different tissues but is specifically found in the neurons of the forebrain and its mRNA is found within the dendrites and the soma of the neuron. The CaMKII that is found in the neurons consist of two subunits of 52 (termed alpha genes) and 60 kDa (beta genes). CaMKII has catalytic and regulatory domains, as well as an ATP-binding domain, and a consensus phosphorylation site (3-7). The binding of Ca2+ auto inhibitory effect and activates the kinase (8). /calmodulin to its regulatory domain releases its This kinase activation results in autophosphorylation at threonine 286 (8). The threonine phosphorylation state of CaMKII can be regulated through PP1/PKA. Whereas PP1 (protein phosphatase 1) dephosphorylates phospho-CaMKII at Thr286, PKA (protein kinase A) prevents this dephosphorylation (9). Autophosphorylation also enables CaMKII to attain an enhanced affinity for NMDA receptors in postsynaptic densities (10-12).
Reference: 1. Hughes K. et al. (2001) J. Biol. Chem. 276: 36008–36013.2. Barria A. et al. (1997) Science 276: 2042–2045.3. Bennet M.K. and Kennedy M.B. (1987) Proc. Natl. Acad. Sci. U.S.A. 84: 1794-1798.4. Broke L., Srinivasan M. and Schulman H. (1995) J. Neurosci. 15: 6797-6808.5. Nghiem P., Saati S. M., Martens C. L., Gardner P. and Schulman H. (1993) J. Biol. Chem. 268: 5471-5479.6. Edman C.F. and Schulman H. (1994) Biochem. Biophys. Acta 1221: 90-102.7. Tombes R.M. and Krystal G.W., (1997) Biochem. Biophys. Acta 13555: 281-292.8. Means A.R. (2000) Mol. Endocrinol. 14: 4–12.9. Makhinson M. et al. (1999) J. Neurosci. 19: 2500–2510.10. Strack S. and Colbran R.J. (1998) J. Biol. Chem. 273: 20689-20692.11. Leonard S.A., Lim I.A., Hemsworth D.E., Horne M.C. and Hell J.W. (1999) Proc. Natl. Acad. Sci. U.S.A. 96: 3239-3244.12. Shen K. and Meyer Y. (1999) Science 284: 162-167.13. Shifman J. M., Choi M. H., Mihalas S, Mayo S. L., Kennedy M. B. 2006 Proc. Natl. Acad. Sci. U.S.A. 103: 13968-13973.

Zusatzinformation

Artikelnummer STRSPC-931D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SPC-931D-DY488
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download