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Cdc7 Antibody (pThr376): APC/Cy7, Polyclonal

Cdc7 Antibody (pThr376): APC/Cy7, Polyclonal
440,15 €
Artikelnummer: STRSPC-934D-APCCY7

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Cdc7 Antibody (pThr376): APC/Cy7, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Cdc7 (pThr376) Polyclonal
Target: Cdc7 (pThr376)
Purification: Peptide Affinity Purified
Specificity: Detects 63.888 kDa.
Conjugate: APC/Cy7
Immunogen Species: Human
Cellular Location: Nucleus
Immunogen: A phospho-specific peptide corresponding to residues surrounding Thr376 of human Cdc7 (AA373-379)
Scientific Background: The Dbf4/Cdc7 protein kinase is essential for the activation of replication origins during S phase. Cdc7/Dbf4 efficiently phosphorylates several proteins that are required for the initiation of DNA replication, including five of the six minichromosome maintenance (Mcm) proteins and the p180 subunit of DNA polymerase a-primase. This protein complex consists of the catalytic subunit Cdc7 associating with the regulatory and activating subunit Dbf4. The kinase activity of the complex is regulated throughout the cell cycle, mainly by fluctuating levels of Dbf4. Cdc7 is consistently expressed throughout the cell cycle, while the expression of Dbf4 is absent during G1 phase and accumulates during S and G2 phases. The anaphase-promoting complex rapidly degrades Dbf4 at the time of chromosome segregation, and the stability of Dbf4 remains low during pre-Start G1 phase. The coordinated degradation of Dbf4 and the time of chromosome separation is important to ensuring that prereplicative complexes, which assemble after chromosome segregation, do not immediately refire.

Zusatzinformation

Artikelnummer STRSPC-934D-APCCY7
Hersteller Stressmarq Biosciences
Herstellernummer SPC-934D-APCCY7
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download