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Chk1 Antibody (pSer345): Dylight 633, Polyclonal

Chk1 Antibody (pSer345): Dylight 633, Polyclonal
391,36 €
Artikelnummer: STRSPC-949D-DY633

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Chk1 Antibody (pSer345): Dylight 633, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Chk1 (pSer345) Polyclonal
Target: Chk1 (pSer345)
Purification: Peptide Affinity Purified
Specificity: Detects 54.42 kDa.
Conjugate: Dylight 633
Immunogen Species: Human
Cellular Location: Cytoplasmic
Immunogen: A phospho-specific peptide corresponding to residues surrounding Ser345 of human Chk1 (AA342-348)
Scientific Background: Chk1 is a protein-serine/threonine kinase required for checkpoint-mediated cell cycle arrest. It also subsequently activates DNA repair (i.e. homologous recombination) by phosphorylating RAD51 or FANCE in response to the presence of damage or unreplicated DNA. It regulates cell cycle progression via several mechanisms: 1) phosphorylation of certain proteins such as CDC25A, CDC25B and CDC25C, promoting their degradation; 2) phosphorylation and activation of p53; 3) phosphorylation and inactivation of TLK1, which consequently prevents TLK1-dependent phosphorylation of chromatin assembly factor ASF1A; 4) phosphorylation of histones and regulating transcription of genes involved in cell-cycle progression regulation; 5) phosphorylation of RB1 to promote its interaction with E2F transcription factors and subsequent cell cycle arrest

Zusatzinformation

Artikelnummer STRSPC-949D-DY633
Hersteller Stressmarq Biosciences
Herstellernummer SPC-949D-DY633
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download