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Choline Acetyltransferase Antibody: Dylight 350, Polyclonal

Choline Acetyltransferase Antibody: Dylight 350, Polyclonal
378,64 €
Artikelnummer: STRSPC-706D-DY350

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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Choline Acetyltransferase Antibody: Dylight 350, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human Choline Acetyltransferase Polyclonal
Target: Choline Acetyltransferase
Purification: Peptide Affinity Purified
Specificity: Predicted molecular weight at ~82.5kDa. Observed molecular weights between 68-70kDa.
Conjugate: Dylight 350
Immunogen Species: Human
Cellular Location: Cytoplasm, Cytosol, Mitochondrion, Nucleus
Immunogen: Synthetic peptide from the N-terminal to the mid-protein of human Choline O-Acetyltrasferase
Scientific Background: Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-choline acetyltransferase a useful specific marker. ChAT is a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease and Down syndrome (1-3).
Reference: 1. Houser C.R., Crawford G.D., Barber R.P., Salvaterra P.M., Vaughn J.E. (1983) Brain Research. 266(1): 97-119.2. Karson C.N., Casanova M.F., Kleinman J.E.m Griffin W.S. (1993) Am J Psychiatry. 150: 454-459. 3. Baskins D.S., et al. (1999) Arch Neurol. 56: 1121-1123.

Zusatzinformation

Artikelnummer STRSPC-706D-DY350
Hersteller Stressmarq Biosciences
Herstellernummer SPC-706D-DY350
Verpackungseinheit 100 µg
Mengeneinheit FL
Reaktivität Human, Mouse (Murine)
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Immunocytochemistry, Immunofluorescence, Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download