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CLK1 Antibody (pSer337 + pThr338): Dylight 488, Polyclonal

CLK1 Antibody (pSer337 + pThr338): Dylight 488, Polyclonal
397,73 €
Artikelnummer: STRSPC-952D-DY488

Verfügbarkeit: Regellieferzeit: Innerhalb 1 - 2 Wochen

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CLK1 Antibody (pSer337 + pThr338): Dylight 488, Polyclonal, Host: Rabbit

Details

Rabbit Anti-Human CLK1 (pSer337 + pThr338) Polyclonal
Target: CLK1 (pSer337 + pThr338)
Purification: Peptide Affinity Purified
Specificity: Detects 57.205 kDa.
Conjugate: Dylight 488
Immunogen Species: Human
Cellular Location: Nucleus
Immunogen: A phospho-specific peptide corresponding to residues surrounding Ser337 and Thr338 of human CLK1 (AA334-341)
Scientific Background: The CDC-like kinase 1 (CLK1) dually phosphorylates serine- and arginine-rich proteins of the spliceosomal complex, which constitutes a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Specifically, CLK1 may mediate the release of specific proteins from nuclear storage sites. Expression of CLK1 may be very low due to a premature stop codon in the mRNA, which leads to nonsense-mediated mRNA decay. CLK1 activity is positively regulated by phosphorylation on either tyrosine residues or serine/thre-onine residues. CLK1 activity is negatively regulated by steric constraints mediated by the N-terminal domain and also by phosphorylation on a subset of serine/threonine residues within the catalytic domain.

Zusatzinformation

Artikelnummer STRSPC-952D-DY488
Hersteller Stressmarq Biosciences
Herstellernummer SPC-952D-DY488
Verpackungseinheit 100 µl
Mengeneinheit FL
Reaktivität Human
Klonalität Polyclonal
Wirt / Host Rabbit
Methode Western Blotting
Isotype Keine Herstellerangabe
Gene ID NCBI (externer Link)
Datenblatt Download
MSDS Download